At the age of 17 I was paying attention in college, but still 
enjoying the student life as much as studying towards my career goals. 
What I wasn’t doing was working at the cutting edge of cancer treatment 
and developing a potential cure.
Angela Zhang is, and she’s just been awarded the $100,000 Grand Prize
 in the Individual category of the Siemens Competition in Math, Science 
& Technology. Her project was entitled “Design of Image-guided, 
Photo-thermal Controlled Drug Releasing Multifunctional Nanosystem for 
the Treatment of Cancer Stem Cells.”
Her creation is being heralded as a “Swiss army knife of cancer 
treatment.” Zhang managed to develop a nanoparticle that can be 
delivered to the site of a tumor through the drug salinomycin. Once 
there it kills the cancer stem cells. However, Zhang went further and 
included both gold and iron-oxide components, which allow for 
non-invasive imaging of the site through MRI and Photoacoustics.
As to why she chose this as her project, Zhang explains that she was 
surprised when looking at the survival rates of patients receiving 
cancer treatment. As cancer stem cells are resistant to many forms of 
cancer treatment, it seemed like an area worth focusing on. Her 
nanoparticle is award-winning due to the fact it has the potential to 
overcome cancer resistance while offering up the ability to monitor the 
effects of the treatment in real-time using existing imaging techniques.
Zhang’s achievement is impressive considering she is only 17 years 
old, but also due to the level of understanding required to create such a
 nanoparticle in the first place. She has spent over 1,000 hours since 
2009 researching and developing the particle, and wants to go on to 
study chemical engineering, biomedical engineering, or physics. Her 
dream job is to be a research professor.
The Siemens Competition
 is in its 13th year and aims to highlight talent at the high school 
level for those interested in science research. Last year 15-year-old 
Benjamin Clark won the Individual category for his work into how stars 
are born. In 2009 Ruoyi Jiang won for his research into chemotherapy 
drug resistance.
I think we can all agree this is a very worthwhile competition, and 
long may it continue if it pushes young minds to create solutions to 
some of our biggest problems.
 
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