Whether it be a family member or friend, most of us, unfortunately,
have had to deal with cancer at some point in our lives. Scientists at
Stanford have uncovered an antibody
that, when administered to human tumors, broke down the cancerous
tumors associated with brain, breast, prostate, liver, ovarian, bowel,
and bladder cancer.
In the human body, there is a protein called CD47. CD47 is found
primarily on healthy blood cells, and it acts as a shield that tells our
immune system not to attack. Stanford scientist Dr. Irving Weissman
found that levels of CD47 on tumors are off the charts,
and therefore the body doesn’t realize that the object is bad and won’t
try to break it down. CD47 is also found on leukemia and lymphoma
cells, and is a potential cure for those as well. Scientists working
with Weissman essentially were able to unmask these cancerous tumors by
administered a single medication: a CD47 antibody. Once uncloaked, our
immune system can attack and break them down for good.
Human tumors were input into mice for the trial. In many but not all
cases, the tumors were seen to shrink and often times disappear. The
tumor stopped growing altogether in nine out of ten mice. In five out of
ten mice, the cancer cells were eliminated completely, and the mice
remained cancer free for at least four months.
It’s important to note that this has not been tested inside humans,
but has been proven to work on human cancerous tumors. Dr. Irving
Weissman said the goal is to now to move forward “quickly but
cautiously.” After recently receiving a $20 million grant, Dr. Weissman
said “We have enough data that I can say I’m confident that this will
move to phase I human trials.”
Healthy blood cells did get destroyed in the process, but were
quickly regenerated. It is speculated that this CD47 antibody may be
available in a pill form within a few years.
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